
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a
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The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are
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Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a
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The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a
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Understanding and analysing the complex phenomena related to elastic wave propagation has been the subject of intense research for many years and has enabled application in numerous fields of technology, including structural health monitoring (SHM). In the course of the rapid advancement of
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When wealth, power and politics cross paths with the criminal underworld… Ethan Marshall, grandson of a former senator, is handsome and charming – and he’s lusting after Lily Black! Working for the Marshalls as a stable manager, Lily has the ideal job for the first time in her life – she loves
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When wealth, power and politics cross paths with the criminal underworld… Ethan Marshall, grandson of a former senator, is handsome and charming – and he’s lusting after Lily Black! Working for the Marshalls as a stable manager, Lily has the ideal job for the first time in her life – she loves
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This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two
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This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed
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Wall bounded turbulent flows are of major importance in industrial and environmental fluid mechanics. The structure of the wall turbulence is intrinsically related to the coherent structures that play a fundamental role in the transport process. The comprehension of their regeneration mechanism is
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The swelling of concrete is a major concern for the owners and operators of dams and hydraulic structures. Faced with irreversible movement of their dams or with observations of cracking processes, operators need to explain the phenomena observed in order to justify safety conditions and in some
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