
Classical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly to be explained in this manner, particularly their effects on the central nervous system. This text
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How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the
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Myopia, the most common disorder of the eye, affects 80% of the population of some countries. Although its basis remains uncertain, recent development of animal models have permitted tests of hypothesis as to myopia's origins. The symposium proceedings cover normal growth of the eye including the
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Composed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more species. Exciting applications are emerging in this field and it is expected that improved
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A panel of internationally renowned experts present papers on cell signalling–an area in which there has been recent important advances. Coverage includes the inositol 1, 4, 5-triphosphate receptor, signal-induced phospholipid degradation cascade and protein kinase C activation, cyclic AMP
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Parkinson's disease, Alzheimer's disease, and motor neuron disease share a significant common feature: selective death of neurons in restricted regions of the brain. This international symposium, held by the Ciba Foundation in 1986, is the first to bring together neurophysiologists working on
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This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity
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Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role. It has been shown that oestrogen acts as a neural growth factor with important influences on the
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The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids – androgens – actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable
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The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids – androgens – actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable
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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known
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This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the
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