Michael Shapiro Fragment-Based Drug Discovery
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Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules – fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the
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Группа авторов Fragment-based Drug Discovery
Купить за 14646.75 RUR
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current
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Hugo Kubinyi Fragment-based Approaches in Drug Discovery
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This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers
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Michael Shapiro J. War Crimes, Atrocity and Justice
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What do we know about war crimes and justice? What are the discursive practices through which the dominant images of war crimes, atrocity and justice are understood? In this wide ranging text, Michael J. Shapiro contrasts the justice-related imagery of the war crimes trial (for example the
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Michael Wiese Drug-Membrane Interactions
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Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better
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Группа авторов Analogue-based Drug Discovery III
Купить за 15409.83 RUR
Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful
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J?nos Fischer Analogue-based Drug Discovery
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The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone
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Chi-Huey Wong Carbohydrate-based Drug Discovery
Купить за 66316.78 RUR
To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with
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Michael D. Coleman Human Drug Metabolism
Купить за 8306.31 RUR
Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core
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Benjamin Miller L. Dynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science
Купить за 9509.17 RUR
Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular
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Ganellin C. Robin Analogue-based Drug Discovery II
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Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor,
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Robert A. Goodnow, Jr. A Handbook for DNA-Encoded Chemistry
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This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening,
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