Didier Rognan Ligand Design for G Protein-coupled Receptors
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G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design. Based on recent examples
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Группа авторов Ligand Design in Metal Chemistry
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The design of ancillary ligands used to modify the structural and reactivity properties of metal complexes has evolved into a rapidly expanding sub-discipline in inorganic and organometallic chemistry. Ancillary ligand design has figured directly in the discovery of new bonding motifs and
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Hugo Kubinyi Structure-based Ligand Design
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Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical
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Andrea Bellelli Reversible Ligand Binding
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Presents the physical background of ligand binding and instructs on how experiments should be designed and analyzed Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions—providing a comprehensive view of the various biochemical
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Tim Storr Ligand Design in Medicinal Inorganic Chemistry
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Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease
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Hugo Kubinyi Fragment-based Approaches in Drug Discovery
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This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers
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Hugo Kubinyi Protein-Ligand Interactions
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The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as
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Группа авторов Protein-Ligand Interactions
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Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key
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Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena
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A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the
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Didier Dumur Zonotopes
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This title focuses on two significant problems in the field of automatic control, in particular state estimation and robust Model Predictive Control under input and state constraints, bounded disturbances and measurement noises. The authors build upon previous results concerning zonotopic
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Didier Daeninckx Missak
Купить за 899.22 RUR
La resistencia francesa contra la ocupaci?n nazi convoc? a partisanos de diversos grupos, predominando socialistas, comunistas, jud?os e inmigrantes antifascistas de distintas nacionalidades. Esta novela relata la historia de uno de ellos: Missak Manouchian y la red de resistentes que dirig?a.
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Didier Cossin Inspiring Stewardship
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Transform from leader to steward to drive growth and make an impact Inspiring Stewardship helps leaders drive sustainable development and growth by balancing short- and long-term objectives amidst competing interests. By examining a range of exceptional individual and organisational stewards
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