
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide
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Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical
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Arun K. Banerjee is one of the foremost experts in the world on the subject of flexible multibody dynamics. This book describes how to build mathermatical models of multibody systems with elastic components. Examples of such systems include the human body itself, construction cranes, cares with
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A comprehensive guide to the latest in phased array antenna analysis and design–the Floquet modal based approach This comprehensive book offers an extensive presentation of a new methodology for phased array antenna analysis based on Floquet modal expansion. Engineers, researchers, and advanced
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The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are
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Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products,
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Decision Making in Systems Engineering and Management is a comprehensive textbook that provides a logical process and analytical techniques for fact-based decision making for the most challenging systems problems. Grounded in systems thinking and based on sound systems engineering principles, the
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A comprehensive approach to the air vehicle design process using the principles of systems engineering Due to the high cost and the risks associated with development, complex aircraft systems have become a prime candidate for the adoption of systems engineering methodologies. This book presents the
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The monography “The controlled molecular magnetism of mono-, bi-and polynuclear complexes based on hydrazones, azomethenes and its analogues” represents the encyclopedic edition reflecting the basic experimental – theoretical aspects concerning new scientific area- magnetochemistry of
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Provides a self-contained description of this important aspect of information processing and decision support technology. Presents basic definitions, principles, applications, and a detailed bibliography. Covers a range of real-world examples including control, data mining, and pattern recognition.
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G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design. Based on recent examples
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